Research

Research Topics

The Anumonwo lab investigates molecular and cellular mechanisms underlying  electrical and mechanical normal and abnormal heart function. Our investigations involve the use of transgenic models and patient-specific, stem cell derived heart cells and computer simulations. 

Specifically, the laboratory utilizes state-of-the-art electrophysiological, molecular and biochemical techniques to probe gating properties of ion channel proteins in normal heart cells  or  such  channel properties in cells from hearts compromised by inherited abnormal genes or damaged by factors after birth. The primary technique includes the patch clamp technique, where a recording probe (a micro/patch electrode ) is introduced into the cell to measure the voltage difference and current flow across the heart cell membrane. The lab also investigates the cell culture of myocytes and uses optical mapping of electrical excitation.